Donor Specific IgG Antibodies (DSA), Class I & II

Donor Specific IgG Antibodies (DSA), Class I & II

Test Name: Donor Specific IgG Antibodies (DSA), Class I & II

What is the test?
Donor Specific Antibodies (DSA) are IgG antibodies in a recipient’s blood that specifically react against HLA (Human Leukocyte Antigen) molecules of a donor. Testing for both Class I and Class II DSA helps assess immunological compatibility, particularly in transplantation.

Why is it done?

• Pre-transplant immunological risk assessment
• Detection of antibodies against a potential donor
• Evaluation of risk for antibody-mediated rejection (AMR)
• Post-transplant monitoring for development or persistence of DSA
• Supporting transplant treatment and follow-up decisions

Sample: Serum
Method: HLA antibody testing / Single Antigen Bead-based assay, as applicable
Reports: Class I & Class II DSA with antibody specificity and relevant antibody strength assessment.

Clinical Significance:
The presence, specificity, and strength of DSA may help clinicians evaluate the recipient’s immune response to the donor and determine the potential risk of transplant rejection.

Note: Results should always be interpreted along with the patient’s clinical condition, HLA typing, crossmatch findings, and transplant history.