Whole Exome Sequencing (WES) -RAPID ( Couple)

COUPLE – Whole Exome Sequencing (WES)

What is Couple Whole Exome Sequencing (WES)?

Couple Whole Exome Sequencing (WES) is an advanced genetic test that analyzes the protein-coding regions (exons) of both partners' DNA. It helps identify disease-causing genetic variants and determines whether the couple carries mutations that could increase the risk of passing inherited disorders to their children.

Why is this test recommended?

• Detects carrier status for thousands of inherited genetic disorders.
• Assesses reproductive risk before pregnancy or during family planning.
• Supports informed decisions regarding conception and prenatal care.
• Helps identify rare genetic conditions not covered by routine carrier screening.

Who should consider this test?

• Couples planning a pregnancy.
• Couples with a family history of inherited disorders.
• Couples with recurrent miscarriages or infertility.
• Consanguineous (blood-related) couples.
• Couples with a previously affected child.

Sample Required

• Peripheral Blood (EDTA) from both partners.

Benefits

• Comprehensive analysis of over 20,000 genes.
• Identifies rare and clinically significant variants.
• Enables personalized genetic counseling.
• Helps reduce the risk of inherited diseases in future generations.
• Provides valuable information for reproductive planning.

Interpretation

• Negative: No clinically significant pathogenic variants detected.
• Carrier Positive: One or both partners carry variants associated with inherited disorders.
• At-Risk Couple: Both partners carry pathogenic variants in the same recessive gene, increasing the chance of having an affected child.
• Results should always be interpreted alongside genetic counseling.

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COUPLE Whole Exome Sequencing (WES)

Plan Parenthood with Confidence! ❤️🧬

✔ Detects inherited genetic disorders in both partners
✔ Comprehensive exome analysis
✔ Supports healthy family planning
✔ Recommended before pregnancy & IVF

Early genetic insights lead to informed decisions.