VDRL(RPR), Flocculation,Titer,CSF

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VDRL, Titre (Quantitative) – Serum | Test Code: V0003c

Test Overview

The VDRL (Venereal Disease Research Laboratory) Titre test is a quantitative blood test used to detect and measure antibodies produced in response to Treponema pallidum, the bacterium responsible for Syphilis.

Unlike the qualitative VDRL test, this test provides a titre value, indicating the concentration of antibodies, which is crucial for:

• Assessing disease activity

• Monitoring treatment effectiveness

• Detecting reinfection or relapse

Specimen Required

• Sample Type: Serum

• Volume: 2–3 mL blood

• Container: Plain (Red/Yellow top tube)

Methodology

• Flocculation Test (Quantitative)

Preparation

• Fasting: Not required

• Special Instructions: Inform clinician about ongoing treatment or past infection

Clinical Significance

1. Diagnosis Support

• Helps confirm suspected syphilis infection along with treponemal tests

2. Disease Monitoring

• Titre levels decrease with successful treatment

• Rising titres may indicate:

  • Treatment failure

  • Reinfection

3. Screening Utility

• Commonly used in:

  • Antenatal screening

  • Blood donor screening

Result Interpretation

⚠️ Note: Results should always be correlated with confirmatory treponemal tests (e.g., TPHA/FTA-ABS).

Limitations

• May produce false positives in conditions such as:

  • Autoimmune diseases

  • Pregnancy

  • Certain viral infections

• Not specific for Treponema pallidum

Turnaround Time (TAT)

• Same day / 24 hours

Use Case Summary

✔ Disease activity assessment
✔ Treatment monitoring
✔ Follow-up testing
✔ Screening in clinical programs

Suggested Add-ons

• TPHA (Treponema Pallidum Hemagglutination)

• FTA-ABS (Fluorescent Treponemal Antibody Test)

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