Estradiol, Serum – E0006
Test Overview
The Estradiol Serum Test (E0006) measures the level of estradiol (E2)—the most potent form of estrogen—in the bloodstream. Estradiol plays a vital role in regulating the female reproductive system, menstrual cycle, fertility, and secondary sexual characteristics. It is also present in males, where it contributes to bone health and hormonal balance.
This test is commonly used to evaluate ovarian function, menstrual irregularities, infertility, and hormonal imbalances in both women and men.
Why This Test is Done
- Assess menstrual cycle disorders (irregular or absent periods)
- Evaluate fertility issues in women
- Monitor ovarian function and follicle development
- Detect early or delayed puberty
- Diagnose hormonal imbalances
- Monitor hormone replacement therapy (HRT)
- Evaluate estrogen levels in men (e.g., gynecomastia cases)
Who Should Take This Test
- Women with irregular menstrual cycles
- Couples facing difficulty conceiving
- Individuals undergoing fertility treatments (IVF/IUI)
- Patients on hormonal therapy
- Men with suspected estrogen imbalance
- Children with signs of early or delayed puberty
Sample Type
Preparation
- No fasting is usually required
- Test timing may depend on the menstrual cycle phase (doctor may advise specific days)
- Inform your doctor about medications or hormone therapy
Normal Reference Ranges (may vary by lab)
Females:
- Follicular Phase: 20 – 350 pg/mL
- Mid-cycle Peak: 150 – 750 pg/mL
- Luteal Phase: 30 – 450 pg/mL
- Postmenopausal: < 20 pg/mL
Males:
Understanding Results
High Estradiol Levels May Indicate:
- Ovarian tumors
- Polycystic Ovary Syndrome (PCOS)
- Pregnancy
- Hyperthyroidism
Low Estradiol Levels May Indicate:
- Menopause
- Ovarian failure
- Hypopituitarism
- Eating disorders or excessive exercise
Clinical Significance
Estradiol testing is crucial for:
- Tracking ovulation and fertility window
- Monitoring assisted reproductive treatments
- Evaluating endocrine disorders
- Assessing bone health and estrogen deficiency
Test Method
- Performed using advanced immunoassay techniques for accurate hormone quantification
Reporting Time
Precautions
- Hormonal levels fluctuate—interpret results with clinical correlation
- Always consult a doctor or endocrinologist for accurate diagnosis
Additional Information
- Also known as: E2 Test, Serum Estradiol Test
- Test Code: E0006
- Can be part of a hormonal profile panel
FAQs
1. When is the best time to take an Estradiol test?
Usually during specific days of the menstrual cycle (often day 2–5), depending on the purpose of testing.
2. Do men need this test?
Yes, especially if there are signs of hormonal imbalance like breast tissue enlargement or infertility.
3. Can medications affect the results?
Yes, hormone therapies, birth control pills, and certain drugs can influence estradiol levels.
4. Is fasting required?
No, fasting is generally not required unless advised.
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