Complement 50 (C50) Level, Serum

Complement 50 (C50) Level, Serum

The Complement 50 (C50) Level Test measures the overall activity of the complement system — an important part of the body’s immune defense mechanism. This test helps evaluate how effectively complement proteins work together to fight infections and inflammation.

Why is this test done?

• To assess immune system function
• To help diagnose autoimmune disorders
• To monitor diseases such as:
  • Lupus (SLE)
  • Rheumatoid arthritis
  • Glomerulonephritis
  • Recurrent infections
• To evaluate complement deficiencies

Symptoms that may require this test

• Frequent infections
• Unexplained inflammation
• Joint pain and swelling
• Skin rashes
• Fatigue
• Kidney-related symptoms

Sample Required

• Sample Type: Serum

Preparation

• Usually no fasting is required
• Follow your doctor’s instructions if any special preparation is advised

Interpretation

• Low C50 levels: May indicate complement deficiency, autoimmune disease, or active immune complex disorders
• High/Normal levels: Usually indicate normal complement activity

Benefits of the Test

• Early detection of immune disorders
• Helps monitor treatment effectiveness
• Supports accurate diagnosis of autoimmune conditions

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