CML BCR-ABL t(9;22) (Chronic Phase) Panel, FISH
Detect the Philadelphia Chromosome with Precision
The CML BCR-ABL t(9;22) (Chronic Phase) Panel by FISH is a specialized diagnostic test used to identify the BCR-ABL1 gene fusion (Philadelphia chromosome) resulting from the t(9;22)(q34;q11) translocation. This genetic abnormality is the hallmark of Chronic Myeloid Leukemia (CML) and is essential for diagnosis, prognosis, and treatment planning.
Why is this test done?
- Detects the BCR-ABL1 fusion gene in suspected CML cases.
- Confirms the presence of the Philadelphia chromosome.
- Supports diagnosis of Chronic Phase CML.
- Helps guide targeted therapy decisions.
- Useful when conventional chromosome analysis is inconclusive.
Recommended for:
- Individuals with suspected Chronic Myeloid Leukemia (CML).
- Patients with persistent high white blood cell counts.
- Cases requiring confirmation of the Philadelphia chromosome.
- Monitoring disease status alongside other molecular tests, when indicated.
Sample Required:
- Peripheral Blood or Bone Marrow (as advised by the clinician).
Method:
- Fluorescence In Situ Hybridization (FISH)
Clinical Significance:
Early detection of the BCR-ABL1 translocation enables timely diagnosis and initiation of targeted therapy, improving disease management and patient outcomes in Chronic Myeloid Leukemia.
Advanced BioCare Laboratories – Delivering accurate molecular and cytogenetic diagnostics for confident clinical decision-making.
