CINtec Plus

CINtec Plus (p16/Ki-67 Dual Stain) Test

What is CINtec Plus?

CINtec Plus is an advanced cervical cancer screening test that detects the simultaneous presence of p16 and Ki-67 proteins in the same cervical cell. Their co-expression suggests abnormal cell cycle changes associated with high-risk HPV infection and an increased likelihood of cervical precancer. It is commonly used to help identify women who may need further evaluation after HPV-positive results or abnormal cervical screening.

Why is this test done?

• Helps identify women at increased risk of cervical precancer (CIN2+)
• Evaluates HPV-related cellular changes
• Assists in deciding whether colposcopy is needed
• Improves accuracy when used alongside HPV and Pap tests
• Supports early detection and timely management of cervical abnormalities

Who should consider this test?

• Women with a positive high-risk HPV test
• Individuals with equivocal or mildly abnormal Pap smear results (e.g., ASC-US, LSIL)
• Patients requiring further assessment before colposcopy
• Women under cervical cancer screening follow-up as advised by their gynecologist

Sample Required

• Cervical cell sample collected during a routine cervical examination (liquid-based cytology).

Preparation

• No fasting required.
• Avoid vaginal medications, douching, or sexual intercourse for 24–48 hours before sample collection, if advised by your healthcare provider.

Benefits

• Early detection of cervical precancerous changes
• Better risk assessment than HPV testing alone in selected patients
• Helps reduce unnecessary colposcopies
• Supports personalized clinical management
• Reliable and evidence-based screening aid

Book Your Test Today

Protect your cervical health with advanced screening. Early detection can make a significant difference. Consult your healthcare provider to know if the CINtec Plus test is right for you.