Chronic Kidney Disease(CKD) gene panel

Chronic Kidney Disease (CKD) Gene Panel

Test Name: Chronic Kidney Disease (CKD) Gene Panel

Overview

The Chronic Kidney Disease (CKD) Gene Panel is a comprehensive genetic test designed to identify disease-causing variants associated with inherited kidney disorders that may lead to chronic kidney disease. This panel analyzes multiple genes linked to structural, functional, and metabolic kidney abnormalities, helping clinicians determine the underlying genetic cause of kidney dysfunction.

Who Should Consider This Test?

• Individuals with unexplained chronic kidney disease
• Early-onset kidney disease
• Family history of kidney disorders or kidney failure
• Congenital anomalies of the kidney and urinary tract (CAKUT)
• Cystic kidney diseases
• Nephrotic syndrome or glomerular disorders
• Tubulointerstitial kidney diseases
• Patients being evaluated for kidney transplantation

Genes Included

The panel evaluates clinically relevant genes associated with:

• Polycystic kidney disease (PKD1, PKD2, etc.)
• Alport syndrome (COL4A3, COL4A4, COL4A5)
• Nephronophthisis-related disorders
• Focal Segmental Glomerulosclerosis (FSGS)
• Congenital nephrotic syndrome
• Tubular and electrolyte disorders
• Inherited renal ciliopathies
• Other hereditary kidney diseases

Clinical Utility

• Identifies the genetic cause of CKD
• Assists in accurate diagnosis and disease classification
• Supports prognosis and disease management
• Guides family screening and genetic counseling
• Helps assess transplant-related risks
• Enables personalized treatment strategies

Sample Required

• Peripheral Blood / EDTA Blood

Methodology

• Clinical Exome Sequencing (CES) / Next-Generation Sequencing (NGS)

Benefits

✔ Early and precise diagnosis
✔ Improved patient management
✔ Informed family planning decisions
✔ Reduced need for invasive diagnostic procedures
✔ Identification of at-risk family members

Reporting

A detailed report is provided with identified pathogenic, likely pathogenic, and clinically significant variants, interpreted according to current international guidelines.

Advanced BioCare Laboratories – Delivering Precision Genetic Diagnostics for Better Kidney Health.