Chromogranin A, Plasma

Chromogranin A (CgA), Plasma

Chromogranin A (CgA), Plasma is a specialized blood test used to help detect and monitor neuroendocrine tumors (NETs). Chromogranin A is a protein released by neuroendocrine cells, and elevated levels may indicate certain hormone-producing tumors or related conditions.

Why is this test done?

• Helps in the diagnosis of neuroendocrine tumors
• Monitors treatment response in NET patients
• Assesses disease progression or recurrence
• Supports evaluation of carcinoid tumors and pheochromocytoma

Symptoms that may require testing

• Flushing or unexplained sweating
• Persistent diarrhea
• Abdominal pain
• Wheezing
• Unexplained weight loss
• High blood pressure episodes

Sample Required

• Plasma sample

Preparation

• Fasting may be recommended as advised by the physician
• Certain medications like proton pump inhibitors (PPIs) may affect results

Interpretation

Higher-than-normal Chromogranin A levels may be associated with:

• Neuroendocrine tumors
• Carcinoid syndrome
• Pheochromocytoma
• Certain gastrointestinal disorders

Results should always be interpreted along with clinical findings and other diagnostic tests.