CDC Crossmatch (T cell & B cell)

CDC Crossmatch (T Cell & B Cell)

Test Overview
CDC Crossmatch (Complement Dependent Cytotoxicity Crossmatch) is a pre-transplant compatibility test performed to detect harmful antibodies in the recipient’s blood against donor T and B lymphocytes. This test plays a crucial role in assessing the risk of organ rejection before transplantation.

Why This Test is Done

• Evaluates donor-recipient compatibility before organ transplant
• Detects preformed anti-HLA antibodies
• Helps reduce the risk of hyperacute rejection
• Commonly used before kidney and other solid organ transplants

Components

• T Cell Crossmatch: Primarily detects antibodies against HLA Class I antigens
• B Cell Crossmatch: Detects antibodies against both HLA Class I and Class II antigens

Sample Required

• Peripheral Blood

Methodology

• Complement Dependent Cytotoxicity (CDC)

Recommended For

• Kidney transplant recipients
• Organ transplant workup
• Pre-transplant immunological assessment

Benefits

• Improves transplant success rates
• Assists in donor selection
• Helps clinicians plan immunosuppressive therapy

Reporting

• Qualitative interpretation with compatibility assessment

Turnaround Time

• As per laboratory protocol

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