BRCA1 & BRCA2 gene analysis and deletion duplication by MLPA

BRCA1 & BRCA2 Gene Analysis and Deletion/Duplication by MLPA

BRCA1 & BRCA2 Gene Analysis and Deletion/Duplication by MLPA is an advanced genetic test used to detect large deletions or duplications (copy number variations) in the BRCA1 and BRCA2 genes, which are strongly associated with hereditary breast and ovarian cancer syndrome.

Why is this test done?

This test helps identify inherited genetic changes that significantly increase the risk of certain cancers, enabling early detection, preventive care, and personalized treatment planning.

Who should consider this test?

• Individuals with a family history of breast, ovarian, pancreatic, or prostate cancer.
• People diagnosed with breast cancer at a young age.
• Patients with bilateral breast cancer or multiple primary cancers.
• Individuals with a known family history of BRCA mutations.
• Family members of individuals carrying BRCA1 or BRCA2 mutations.

What does the test detect?

• Large deletions in the BRCA1 and BRCA2 genes.
• Large duplications in the BRCA1 and BRCA2 genes.
• Copy number variations (CNVs) that may not be detected by routine DNA sequencing.

Sample Required

• Peripheral blood (EDTA)

Method

• MLPA (Multiplex Ligation-dependent Probe Amplification)

Benefits

• Detects clinically significant BRCA gene alterations missed by standard sequencing.
• Assists in hereditary cancer risk assessment.
• Supports personalized cancer screening and prevention strategies.
• Helps guide treatment decisions, including targeted therapies.
• Enables genetic counselling and risk evaluation for family members.

When is this test recommended?

• Strong family history of hereditary cancers.
• Early-onset breast or ovarian cancer.
• Male breast cancer.
• Triple-negative breast cancer diagnosed at a young age.
• Before preventive risk-reducing interventions or family genetic screening.

Why choose Advanced BioCare Laboratories?

• Advanced molecular diagnostics with high-quality standards.
• Accurate MLPA-based copy number analysis.
• Reliable reports interpreted by experienced specialists.
• Comprehensive support for clinicians and genetic counselling.

Book your BRCA1 & BRCA2 MLPA test today for accurate hereditary cancer risk assessment and informed healthcare decisions.