Beta 2 Microglobulin, Serum
Overview
Beta 2 Microglobulin (B2M), Serum is a blood test used to measure the level of beta 2 microglobulin, a small protein found on the surface of many cells, especially white blood cells. It is released into the blood during normal cell turnover and is filtered by the kidneys.
This test is commonly used to help evaluate:
- Multiple myeloma
- Lymphoma and leukemia
- Kidney function
- Immune system disorders
- Monitoring certain cancers and treatment response
Why This Test is Done
Your doctor may recommend this test if you have:
- Unexplained fatigue or weakness
- Swollen lymph nodes
- Suspected blood cancers
- Kidney disease
- Ongoing immune or inflammatory conditions
It is also used to:
- Assess disease severity
- Monitor progression of multiple myeloma or lymphoma
- Evaluate treatment effectiveness
Sample Required
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Sample Type: Blood (Serum)
-
Fasting Required: No special fasting required
Normal Reference Range
Reference ranges may vary slightly between laboratories, but generally:
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Normal Range: Approximately 0.7 – 1.8 mg/L
Increased Beta 2 Microglobulin Levels May Indicate
- Multiple myeloma
- Lymphoma
- Leukemia
- Kidney dysfunction
- Chronic inflammation
- Viral infections
- Autoimmune disorders
Preparation Before the Test
Usually, no special preparation is needed. Inform your doctor about:
- Current medications
- Kidney-related problems
- Ongoing treatments or chemotherapy
Interpretation of Results
Higher-than-normal levels do not confirm a specific disease on their own. Results are interpreted along with:
- Clinical symptoms
- Kidney function tests
- Imaging studies
- Other blood investigations
Important Notes
- Elevated B2M levels can occur due to both cancer and kidney disease.
- This test is often used for monitoring rather than initial diagnosis alone.
- Follow-up testing may be required for accurate assessment.
Trusted Diagnostic Services
For reliable pathology testing and accurate reports, choose certified diagnostic laboratories with experienced medical professionals.
