Allergen - ?EPHALEXIN by EIA, Serum
APML PML-RARA t(15;17), FISH
The APML PML-RARA t(15;17), FISH test is a specialized genetic investigation used to detect the PML-RARA gene rearrangement associated with Acute Promyelocytic Leukemia (APML). This chromosomal translocation, written as t(15;17), is a hallmark abnormality in APML and helps confirm the diagnosis quickly and accurately.
Why This Test Is Done
- Helps diagnose Acute Promyelocytic Leukemia (APML)
- Detects the PML-RARA fusion gene
- Supports early treatment decisions
- Monitors response to therapy and remission status
- Useful in relapse evaluation
Test Method
The test is performed using FISH (Fluorescence In Situ Hybridization) technology, which identifies specific genetic abnormalities in blood or bone marrow cells using fluorescent probes.
Sample Required
- Bone marrow aspirate or peripheral blood sample
Preparation
- No special preparation or fasting is required.
Benefits of the Test
- Highly sensitive and specific
- Rapid detection of APML-associated translocation
- Assists in targeted treatment planning
- Enables timely clinical intervention
When the Test May Be Recommended
- Suspected acute leukemia symptoms
- Abnormal CBC or peripheral smear findings
- Monitoring APML treatment progress
- Suspected recurrence of APML
Symptoms Associated with APML
- Fatigue and weakness
- Easy bruising or bleeding
- Frequent infections
- Fever
- Shortness of breath
Early detection of the PML-RARA translocation is critical because APML is a highly treatable leukemia when diagnosed promptly.
