ACTH Stimulation Test - For 17 OH progesterone, Serum

ACTH Stimulation Test – For 17 OH Progesterone, Serum

Overview
The ACTH Stimulation Test for 17-OH Progesterone measures how your adrenal glands respond to adrenocorticotropic hormone (ACTH). It is primarily used to diagnose or confirm Congenital Adrenal Hyperplasia (CAH), especially due to 21-hydroxylase deficiency, and to evaluate adrenal gland function.

Why is this test done?

• Diagnose Congenital Adrenal Hyperplasia (CAH)
• Differentiate CAH from other hormonal disorders
• Investigate excessive androgen (male hormone) production
• Evaluate adrenal gland function
• Assess unexplained irregular menstrual cycles, infertility, or excessive hair growth in women
• Monitor patients undergoing treatment for CAH

Symptoms that may require this test

• Early puberty
• Excess facial or body hair (Hirsutism)
• Irregular or absent menstrual periods
• Acne associated with hormonal imbalance
• Infertility
• Ambiguous genitalia in newborns
• Salt-wasting symptoms (vomiting, dehydration, low blood pressure)

Sample Required

• Serum (Blood Sample)

Preparation

• Follow your doctor's instructions regarding the timing of sample collection.
• The test involves a baseline blood sample followed by ACTH administration and additional blood samples at specified intervals.
• Inform your healthcare provider about all medications you are taking, especially steroid medications, as they may affect the results.

Interpretation

• Normal Response: Indicates normal adrenal hormone production.
• Elevated Stimulated 17-OH Progesterone: Suggests Congenital Adrenal Hyperplasia (most commonly 21-hydroxylase deficiency).
• Results should always be interpreted along with clinical findings and other hormone tests by a qualified physician.

Who should consider this test?

• Newborns suspected of CAH
• Children with early signs of puberty
• Women with irregular periods, infertility, or hirsutism
• Individuals with suspected adrenal disorders
• Patients being monitored for CAH treatment

Benefits

• Early detection of adrenal disorders
• Accurate diagnosis of CAH
• Supports appropriate treatment planning
• Helps monitor treatment effectiveness
• Reduces the risk of complications through timely intervention