{"product_id":"chromosomal-microarraycma315k-affymetrix-cytoscan-optima","title":"Chromosomal  Microarray(CMA315k) -  Affymetrix  Cytoscan Optima","description":"\u003cp\u003eAmniotic Fluid\/ Chorionic Villus Sample\/Peripheral Venous Blood\/Cord blood,\/Extracted DNA\/Dry Blood Spot\/POC\u003c\/p\u003e\n\u003ch1 data-section-id=\"1k06jkr\" data-start=\"0\" data-end=\"63\"\u003eChromosomal Microarray (CMA315k) – Affymetrix CytoScan Optima\u003c\/h1\u003e\n\u003ch2 data-section-id=\"1qgrpps\" data-start=\"65\" data-end=\"81\"\u003eTest Overview\u003c\/h2\u003e\n\u003cp data-start=\"82\" data-end=\"305\"\u003eChromosomal Microarray Analysis (CMA315k) using the \u003cstrong data-start=\"134\" data-end=\"173\"\u003eAffymetrix CytoScan Optima platform\u003c\/strong\u003e is an advanced genetic test designed to detect chromosomal abnormalities at a much higher resolution than conventional karyotyping.\u003c\/p\u003e\n\u003cp data-start=\"307\" data-end=\"328\"\u003eThis test identifies:\u003c\/p\u003e\n\u003cul data-start=\"329\" data-end=\"536\"\u003e\n\u003cli data-section-id=\"tpd5p1\" data-start=\"329\" data-end=\"345\"\u003eMicrodeletions\u003c\/li\u003e\n\u003cli data-section-id=\"om8e63\" data-start=\"346\" data-end=\"365\"\u003eMicroduplications\u003c\/li\u003e\n\u003cli data-section-id=\"66m5d1\" data-start=\"366\" data-end=\"397\"\u003eCopy Number Variations (CNVs)\u003c\/li\u003e\n\u003cli data-section-id=\"yw6urr\" data-start=\"398\" data-end=\"443\"\u003eAneuploidies (extra or missing chromosomes)\u003c\/li\u003e\n\u003cli data-section-id=\"1i2xtmk\" data-start=\"444\" data-end=\"478\"\u003eLoss of Heterozygosity (LOH\/AOH)\u003c\/li\u003e\n\u003cli data-section-id=\"1n8aqcu\" data-start=\"479\" data-end=\"505\"\u003eUniparental Disomy (UPD)\u003c\/li\u003e\n\u003cli data-section-id=\"1ifubwm\" data-start=\"506\" data-end=\"536\"\u003eCertain mosaic abnormalities\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"538\" data-end=\"587\"\u003eThe CytoScan Optima array contains approximately:\u003c\/p\u003e\n\u003cul data-start=\"588\" data-end=\"766\"\u003e\n\u003cli data-section-id=\"1v2y9jb\" data-start=\"588\" data-end=\"613\"\u003e\u003cstrong data-start=\"590\" data-end=\"613\"\u003e315,608 CNV markers\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli data-section-id=\"1efbe7e\" data-start=\"614\" data-end=\"766\"\u003e\n\u003cstrong data-start=\"616\" data-end=\"639\"\u003e148,450 SNP markers\u003c\/strong\u003e\u003cbr\u003ewith enhanced coverage of clinically significant prenatal and postnatal genomic regions. \u003cspan class=\"\" data-state=\"closed\"\u003e\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 data-section-id=\"141rfwj\" data-start=\"768\" data-end=\"792\"\u003eClinical Applications\u003c\/h2\u003e\n\u003cp data-start=\"793\" data-end=\"831\"\u003eThis test is commonly recommended for:\u003c\/p\u003e\n\u003cul data-start=\"832\" data-end=\"1171\"\u003e\n\u003cli data-section-id=\"za4koz\" data-start=\"832\" data-end=\"853\"\u003eDevelopmental delay\u003c\/li\u003e\n\u003cli data-section-id=\"kgfofc\" data-start=\"854\" data-end=\"879\"\u003eIntellectual disability\u003c\/li\u003e\n\u003cli data-section-id=\"nj60mf\" data-start=\"880\" data-end=\"907\"\u003eAutism spectrum disorders\u003c\/li\u003e\n\u003cli data-section-id=\"1ibto9\" data-start=\"908\" data-end=\"939\"\u003eMultiple congenital anomalies\u003c\/li\u003e\n\u003cli data-section-id=\"1u98rc3\" data-start=\"940\" data-end=\"961\"\u003eDysmorphic features\u003c\/li\u003e\n\u003cli data-section-id=\"1b9beum\" data-start=\"962\" data-end=\"988\"\u003eRecurrent pregnancy loss\u003c\/li\u003e\n\u003cli data-section-id=\"a53ici\" data-start=\"989\" data-end=\"1028\"\u003ePrenatal abnormal ultrasound findings\u003c\/li\u003e\n\u003cli data-section-id=\"12yzwyj\" data-start=\"1029\" data-end=\"1088\"\u003eHigh-risk Double Marker \/ Quadruple Marker \/ NIPT results\u003c\/li\u003e\n\u003cli data-section-id=\"bh2als\" data-start=\"1089\" data-end=\"1122\"\u003eSuspected chromosomal syndromes\u003c\/li\u003e\n\u003cli data-section-id=\"go50f1\" data-start=\"1123\" data-end=\"1147\"\u003eInfertility evaluation\u003c\/li\u003e\n\u003cli data-section-id=\"ye0c9a\" data-start=\"1148\" data-end=\"1171\"\u003eBad obstetric history\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"1173\" data-end=\"1343\"\u003eThe American College of Medical Genetics (ACMG) recommends CMA as a first-tier test for several unexplained developmental disorders. \u003cspan class=\"\" data-state=\"closed\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 data-section-id=\"t2zcgw\" data-start=\"1345\" data-end=\"1369\"\u003eTechnology Highlights\u003c\/h2\u003e\n\u003ch3 data-section-id=\"u5tviu\" data-start=\"1370\" data-end=\"1409\"\u003eAffymetrix CytoScan Optima Features\u003c\/h3\u003e\n\u003cul data-start=\"1410\" data-end=\"1683\"\u003e\n\u003cli data-section-id=\"tbbfem\" data-start=\"1410\" data-end=\"1446\"\u003eWhole genome chromosomal screening\u003c\/li\u003e\n\u003cli data-section-id=\"ttw5dz\" data-start=\"1447\" data-end=\"1507\"\u003eEnhanced interrogation of 396 clinically important regions\u003c\/li\u003e\n\u003cli data-section-id=\"vvp3pc\" data-start=\"1508\" data-end=\"1566\"\u003eDetects gains\/losses not visible in standard karyotyping\u003c\/li\u003e\n\u003cli data-section-id=\"nmyqjb\" data-start=\"1567\" data-end=\"1617\"\u003eSNP-based analysis for LOH\/AOH and UPD detection\u003c\/li\u003e\n\u003cli data-section-id=\"798lqn\" data-start=\"1618\" data-end=\"1683\"\u003eFaster and more comprehensive than multiple targeted FISH tests\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"1685\" data-end=\"1714\"\u003eTypical reporting resolution:\u003c\/p\u003e\n\u003cul data-start=\"1715\" data-end=\"1836\"\u003e\n\u003cli data-section-id=\"1vt9yrf\" data-start=\"1715\" data-end=\"1743\"\u003e~500 kb–1 Mb for deletions\u003c\/li\u003e\n\u003cli data-section-id=\"fdqrnf\" data-start=\"1744\" data-end=\"1770\"\u003e~1–2 Mb for duplications\u003c\/li\u003e\n\u003cli data-section-id=\"7nig3\" data-start=\"1771\" data-end=\"1836\"\u003e~5 Mb for LOH\/AOH regions \u003cspan class=\"\" data-state=\"closed\"\u003e\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 data-section-id=\"1bcglrj\" data-start=\"1838\" data-end=\"1860\"\u003eSample Requirements\u003c\/h2\u003e\n\u003cp data-start=\"1861\" data-end=\"1889\"\u003eCommon sample types include:\u003c\/p\u003e\n\u003cul data-start=\"1890\" data-end=\"2027\"\u003e\n\u003cli data-section-id=\"w826d7\" data-start=\"1890\" data-end=\"1915\"\u003ePeripheral blood (EDTA)\u003c\/li\u003e\n\u003cli data-section-id=\"1urjby8\" data-start=\"1916\" data-end=\"1932\"\u003eAmniotic fluid\u003c\/li\u003e\n\u003cli data-section-id=\"1n8h9dw\" data-start=\"1933\" data-end=\"1964\"\u003eChorionic villus sample (CVS)\u003c\/li\u003e\n\u003cli data-section-id=\"1dnp8a4\" data-start=\"1965\" data-end=\"1995\"\u003eProducts of conception (POC)\u003c\/li\u003e\n\u003cli data-section-id=\"1g67kao\" data-start=\"1996\" data-end=\"2027\"\u003eFresh tissue (selected cases)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 data-section-id=\"1ko8sy6\" data-start=\"2029\" data-end=\"2047\"\u003eTurnaround Time\u003c\/h2\u003e\n\u003cp data-start=\"2048\" data-end=\"2072\"\u003eTypical turnaround time:\u003c\/p\u003e\n\u003cul data-start=\"2073\" data-end=\"2185\"\u003e\n\u003cli data-section-id=\"1eezyyg\" data-start=\"2073\" data-end=\"2185\"\u003e\n\u003cstrong data-start=\"2075\" data-end=\"2097\"\u003e10–14 working days\u003c\/strong\u003e depending on sample type and laboratory workflow. \u003cspan class=\"\" data-state=\"closed\"\u003e\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 data-section-id=\"1344z7h\" data-start=\"2187\" data-end=\"2200\"\u003eAdvantages\u003c\/h2\u003e\n\u003cul data-start=\"2201\" data-end=\"2434\"\u003e\n\u003cli data-section-id=\"ulfd5e\" data-start=\"2201\" data-end=\"2251\"\u003eHigher sensitivity than conventional karyotyping\u003c\/li\u003e\n\u003cli data-section-id=\"3y8l7h\" data-start=\"2252\" data-end=\"2302\"\u003eDetects submicroscopic chromosomal abnormalities\u003c\/li\u003e\n\u003cli data-section-id=\"8wf7c3\" data-start=\"2303\" data-end=\"2325\"\u003eGenome-wide analysis\u003c\/li\u003e\n\u003cli data-section-id=\"1vxqovo\" data-start=\"2326\" data-end=\"2379\"\u003eUseful for prenatal and pediatric genetic diagnosis\u003c\/li\u003e\n\u003cli data-section-id=\"1qy5xjf\" data-start=\"2380\" data-end=\"2434\"\u003eCan identify clinically relevant CNVs missed by FISH\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 data-section-id=\"bisuce\" data-start=\"2436\" data-end=\"2450\"\u003eLimitations\u003c\/h2\u003e\n\u003cp data-start=\"2451\" data-end=\"2491\"\u003eThis test generally does \u003cstrong data-start=\"2476\" data-end=\"2483\"\u003enot\u003c\/strong\u003e detect:\u003c\/p\u003e\n\u003cul data-start=\"2492\" data-end=\"2704\"\u003e\n\u003cli data-section-id=\"1iwjta6\" data-start=\"2492\" data-end=\"2517\"\u003eBalanced translocations\u003c\/li\u003e\n\u003cli data-section-id=\"16b656u\" data-start=\"2518\" data-end=\"2530\"\u003eInversions\u003c\/li\u003e\n\u003cli data-section-id=\"19v78t9\" data-start=\"2531\" data-end=\"2571\"\u003eSmall gene mutations \/ point mutations\u003c\/li\u003e\n\u003cli data-section-id=\"1w9w4uq\" data-start=\"2572\" data-end=\"2598\"\u003eVery low-level mosaicism\u003c\/li\u003e\n\u003cli data-section-id=\"gb7g9s\" data-start=\"2599\" data-end=\"2621\"\u003eEpigenetic disorders\u003c\/li\u003e\n\u003cli data-section-id=\"mri9l0\" data-start=\"2622\" data-end=\"2704\"\u003eCertain tiny indels below assay resolution \u003cspan class=\"\" data-state=\"closed\"\u003e\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 data-section-id=\"7m9mz3\" data-start=\"2706\" data-end=\"2723\"\u003eInterpretation\u003c\/h2\u003e\n\u003cp data-start=\"2724\" data-end=\"2751\"\u003eResults are categorized as:\u003c\/p\u003e\n\u003cul data-start=\"2752\" data-end=\"2835\"\u003e\n\u003cli data-section-id=\"1t1tta3\" data-start=\"2752\" data-end=\"2760\"\u003eNormal\u003c\/li\u003e\n\u003cli data-section-id=\"43ekmk\" data-start=\"2761\" data-end=\"2773\"\u003ePathogenic\u003c\/li\u003e\n\u003cli data-section-id=\"17edfjm\" data-start=\"2774\" data-end=\"2793\"\u003eLikely pathogenic\u003c\/li\u003e\n\u003cli data-section-id=\"p4e8g5\" data-start=\"2794\" data-end=\"2835\"\u003eVariant of uncertain significance (VUS)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"2837\" data-end=\"2912\"\u003eGenetic counseling is often recommended for abnormal or uncertain findings.\u003c\/p\u003e\n\u003ch2 data-section-id=\"8rrbz2\" data-start=\"2914\" data-end=\"2934\"\u003eAlternative Names\u003c\/h2\u003e\n\u003cul data-start=\"2935\" data-end=\"3058\"\u003e\n\u003cli data-section-id=\"1lv9f7f\" data-start=\"2935\" data-end=\"2945\"\u003eCMA 315K\u003c\/li\u003e\n\u003cli data-section-id=\"15iy6uc\" data-start=\"2946\" data-end=\"2968\"\u003eCytoscan Optima 315K\u003c\/li\u003e\n\u003cli data-section-id=\"1qk6wup\" data-start=\"2969\" data-end=\"3002\"\u003eChromosomal Microarray Analysis\u003c\/li\u003e\n\u003cli data-section-id=\"1qkgscm\" data-start=\"3003\" data-end=\"3019\"\u003eSNP Microarray\u003c\/li\u003e\n\u003cli data-section-id=\"xdt6h9\" data-start=\"3020\" data-end=\"3058\"\u003eCytoMicroarray Low Resolution (315K)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 data-section-id=\"1ya29xk\" data-start=\"3060\" data-end=\"3083\"\u003eReference Technology\u003c\/h2\u003e\n\u003cp data-start=\"3084\" data-end=\"3226\"\u003eThe test uses the \u003cspan class=\"hover:entity-accent entity-underline inline cursor-pointer align-baseline\"\u003e\u003cspan class=\"whitespace-normal\"\u003eThermo Fisher Scientific\u003c\/span\u003e\u003c\/span\u003e \/ Affymetrix CytoScan Optima microarray platform for genome-wide chromosomal analysis.\u003c\/p\u003e","brand":"Lifecell Diagnostics","offers":[{"title":"Default Title","offer_id":44007226802311,"sku":null,"price":10290.0,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0691\/4241\/3447\/files\/68c7ef4e-a616-44d2-a542-a0ccd40bdb26.png?v=1779172710","url":"https:\/\/ourdermastore.com\/products\/chromosomal-microarraycma315k-affymetrix-cytoscan-optima","provider":"Ourdermastore ","version":"1.0","type":"link"}